Not tried with interconnects, and we have Monster brand which are labelled directional because at the finish end there is a little wrap of white paper with an arrow on it, that pretty much falls off after about a week, so I have taped it on. Hmm, is it important? Why put a bit of not very sticky label on then? Oh wait, it's Monster, and everyone loves them I have some Planet Waves guitar leads, which have a direction, and the Amp end has "shielded end" written on it. I have hooked them up the wrong way a few times and something just didn't sound right. Dunno how to explain what was wrong, it was something in the feel. Maybe I was having a funny five minutes and just couldn't play properly - it happens.